Assay Detail
Binding
CHEMBL809120
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In vitro inhibition of pig liver microsomal squalene epoxidase (SE) by measuring the extend of cholesterol radiolabeling after incubation with [14C]mevalonate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of new potential photoaffinity labels for mammalian squalene epoxidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.71 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15929 | — | — | 1 | 7.70 |
| CHEMBL16178 | — | — | 1 | 7.00 |
| CHEMBL267332 | — | — | 1 | 6.57 |
| CHEMBL16004 | — | — | 1 | 6.28 |
| CHEMBL16120 | — | — | 1 | 6.02 |
| CHEMBL15811 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15929 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL16178 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL267332 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL16004 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL16120 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL15811 | — | IC50 | > | 100000.0 | nM | - |