Assay Detail
Functional
CHEMBL694540
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Tested in vitro for antagonist activity against H3 receptor of guinea pig jejunum.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Jejunum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.97 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90063 | — | — | 1 | 6.00 |
| CHEMBL94249 | — | — | 1 | 6.00 |
| CHEMBL91353 | HOMOHISTAMINE | — | 1 | 5.90 |
| CHEMBL92694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90063 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL94249 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL91353 | HOMOHISTAMINE | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL92694 | — | Kd | > | 1000000.0 | nM | - |