Assay Detail
Functional
CHEMBL694608
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Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell monolayers of HSV-2 MS Vero cells by 50%
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.40 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.21 |
| CHEMBL318153 | EDOXUDINE | 2.0 | 1 | 4.23 |
| CHEMBL3142954 | — | — | 1 | 4.11 |
| CHEMBL3142955 | — | — | 1 | 4.06 |
| CHEMBL3142953 | — | — | 1 | - |
| CHEMBL3142947 | — | — | 1 | - |
| CHEMBL610413 | — | — | 1 | - |
| CHEMBL611888 | — | — | 1 | - |
| CHEMBL3142948 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL318153 | EDOXUDINE | EC50 | = | 58500.0 | nM | 4.23 |
| CHEMBL3142954 | — | EC50 | = | 77800.0 | nM | 4.11 |
| CHEMBL3142955 | — | EC50 | = | 87700.0 | nM | 4.06 |
| CHEMBL3142953 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL3142947 | — | EC50 | = | 105000.0 | nM | - |
| CHEMBL610413 | — | EC50 | > | 256000.0 | nM | - |
| CHEMBL611888 | — | EC50 | > | 228000.0 | nM | - |
| CHEMBL3142948 | — | EC50 | > | 322000.0 | nM | - |