Assay Detail
Functional
CHEMBL694654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against HIV-1 IIIB strain
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.21 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338047 | — | — | 2 | 9.24 |
| CHEMBL338936 | — | — | 2 | 8.74 |
| CHEMBL339511 | — | — | 2 | 7.80 |
| CHEMBL128931 | — | — | 2 | 7.70 |
| CHEMBL129144 | — | — | 2 | 7.17 |
| CHEMBL57733 | — | — | 2 | 6.51 |
| CHEMBL128812 | — | — | 2 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338047 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL338936 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL338047 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL339511 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL128931 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL338936 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL129144 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL128931 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL57733 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL339511 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL57733 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL128812 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL129144 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL128812 | — | IC50 | = | 3400.0 | nM | 5.47 |