Assay Detail
Functional
CHEMBL694688
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The compound was evaluated for the cytotoxicity against human SKOV-3 (ovarian) tumor cell lines.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemical synthesis and cytotoxicity of some azinomycin analogues devoid of the 1-azabicyclo[3.1.0]hexane subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.49 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.70 |
| CHEMBL78703 | — | — | 1 | 5.90 |
| CHEMBL312481 | — | — | 1 | 5.64 |
| CHEMBL80331 | — | — | 1 | 5.53 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.36 |
| CHEMBL78313 | — | — | 1 | 5.29 |
| CHEMBL311823 | — | — | 1 | 5.14 |
| CHEMBL311864 | — | — | 1 | 4.92 |
| CHEMBL78644 | — | — | 1 | 4.89 |
| CHEMBL78657 | — | — | 1 | - |
| CHEMBL78645 | — | — | 1 | - |
| CHEMBL78745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL78703 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL312481 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL80331 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL78313 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL311823 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL311864 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL78644 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL78657 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL78645 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL78745 | — | IC50 | > | 25000.0 | nM | - |