Assay Detail
Functional
CHEMBL694716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro effective concentration required to inhibit towne strain of human cytomegalovirus (HCMV) replication in HFF cell line
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.03 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | 6.34 |
| CHEMBL155623 | — | — | 1 | 5.46 |
| CHEMBL157102 | — | — | 1 | 5.44 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.39 |
| CHEMBL152335 | — | — | 1 | 4.82 |
| CHEMBL151794 | — | — | 1 | 4.50 |
| CHEMBL2111213 | — | — | 1 | 4.48 |
| CHEMBL154409 | — | — | 1 | 4.42 |
| CHEMBL347817 | — | — | 1 | 4.41 |
| CHEMBL152780 | — | — | 1 | - |
| CHEMBL152418 | — | — | 1 | - |
| CHEMBL2111211 | — | — | 1 | - |
| CHEMBL2111212 | — | — | 1 | - |
| CHEMBL513554 | — | — | 1 | - |
| CHEMBL357549 | — | — | 1 | - |
| CHEMBL359127 | — | — | 1 | - |
| CHEMBL421982 | — | — | 1 | - |
| CHEMBL153255 | — | — | 1 | - |
| CHEMBL345346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265948 | FILOCICLOVIR | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL155623 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL157102 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL152335 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL151794 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2111213 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL154409 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL347817 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL152780 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL152418 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2111211 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2111212 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL513554 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL357549 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL359127 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL421982 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL153255 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL345346 | — | EC50 | > | 100000.0 | nM | - |