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Assay Detail

CHEMBL694791

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Binding
Inhibitory activity against IgE receptor
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Low affinity immunoglobulin epsilon Fc receptor (CHEMBL2940)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective inhibition of low affinity IgE receptor (CD23) processing: P1' bicyclomethyl substituents.
Bailey S, Bolognese B, Faller A, Louis-Flamberg P, MacPherson DT, Mayer RJ, Marshall LA, Milner PH, Mistry J, Smith DG, Ward JG.
Bioorg Med Chem Lett (1999) 9 : 3165 -3170
PubMed 10560745 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.82 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL432583 1 7.70
CHEMBL323228 1 7.70
CHEMBL322050 1 7.70
CHEMBL2111687 1 7.16
CHEMBL2112477 1 7.16
CHEMBL110713 1 7.10
CHEMBL110546 1 7.00
CHEMBL316550 1 7.00
CHEMBL108412 1 6.66
CHEMBL108737 1 6.64
CHEMBL110667 1 6.50
CHEMBL322138 1 6.40
CHEMBL108842 1 6.22
CHEMBL106444 1 6.12
CHEMBL106233 1 6.00
CHEMBL92762 1 6.00
CHEMBL110617 1 -
CHEMBL320112 1 -
CHEMBL325583 1 -
CHEMBL265763 1 -
CHEMBL326422 1 -
CHEMBL321288 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL432583 IC50 = 20.0 nM 7.70
CHEMBL323228 IC50 = 20.0 nM 7.70
CHEMBL322050 IC50 = 20.0 nM 7.70
CHEMBL2111687 IC50 = 70.0 nM 7.16
CHEMBL2112477 IC50 = 70.0 nM 7.16
CHEMBL110713 IC50 = 80.0 nM 7.10
CHEMBL110546 IC50 = 100.0 nM 7.00
CHEMBL316550 IC50 = 100.0 nM 7.00
CHEMBL108412 IC50 = 220.0 nM 6.66
CHEMBL108737 IC50 = 230.0 nM 6.64
CHEMBL110667 IC50 = 320.0 nM 6.50
CHEMBL322138 IC50 = 400.0 nM 6.40
CHEMBL108842 IC50 = 600.0 nM 6.22
CHEMBL106444 IC50 = 760.0 nM 6.12
CHEMBL106233 IC50 = 1000.0 nM 6.00
CHEMBL92762 IC50 = 1000.0 nM 6.00
CHEMBL110617 IC50 > 1000.0 nM -
CHEMBL320112 IC50 > 10000.0 nM -
CHEMBL325583 IC50 > 20000.0 nM -
CHEMBL265763 IC50 > 20000.0 nM -
CHEMBL326422 IC50 > 10000.0 nM -
CHEMBL321288 IC50 > 1000.0 nM -