Assay Detail
Functional
CHEMBL694854
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Rb efflux in human T-cells; 1-10
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell line |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9484 | CLOFILIUM | 2.0 | 1 | 6.00 |
| CHEMBL473 | DOFETILIDE | 4.0 | 1 | 6.00 |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | 6.00 |
| CHEMBL471 | SOTALOL | 4.0 | 1 | 6.00 |
| CHEMBL9324 | TETRYLAMMONIUM | 2.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9484 | CLOFILIUM | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL473 | DOFETILIDE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL472 | GLYBURIDE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL471 | SOTALOL | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL9324 | TETRYLAMMONIUM | IC50 | = | 1000.0 | nM | 6.00 |