Compound Detail
CHEMBL9484
CLOFILIUM 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL9484 |
| Name | CLOFILIUM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | WPSYTTKBGAZSCX-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
2
Known Names
Molecular Properties
339.0
MW (Da)
6.49
ALogP
0
HBA
0
HBD
0.0
PSA (Ų)
0.28
QED
1
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 3 meas. best 7.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 7.9 | 7.36 | 12.6 | 2 |
| T-cell line CHEMBL614685 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 12.59 | nM | 7.9 | Inhibition of human ERG | 21185626 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 150.0 | nM | 6.82 | Inhibitory concentration against IKr potassium channel | 15324906 |
| T-cell line | IC50 | = | 1000.0 | nM | 6.0 | In vitro inhibition of Rb efflux in human T-cells; 1-10 | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3681900 | 10.1021/jm00395a021 | Canis familiaris | 9 |
| 3572962 | 10.1021/jm00388a001 | Canis familiaris | 5 |
| 2308138 | 10.1021/jm00165a003 | Cavia porcellus | 3 |
| - | 10.1016/S0960-894X(97)00163-7 | T-cell line | 1 |
| 15324906 | 10.1016/j.bmcl.2004.06.070 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 21185626 | 10.1016/j.ejmech.2010.11.042 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine