Assay Detail
Functional
CHEMBL694889
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Histamine-induced inhibition of forskolin- stimulated cAMP accumulation in SK-N-MC cells overexpressing the human Histamine H3 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | SK-N-MC |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 9.08 | 9.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129542 | JNJ-5207852 | — | 1 | 9.84 |
| CHEMBL129411 | — | — | 1 | 9.71 |
| CHEMBL129306 | — | — | 1 | 9.64 |
| CHEMBL339867 | — | — | 1 | 9.27 |
| CHEMBL126904 | — | — | 1 | 8.05 |
| CHEMBL337942 | — | — | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129542 | JNJ-5207852 | Kd | = | 0.1445 | nM | 9.84 |
| CHEMBL129411 | — | Kd | = | 0.195 | nM | 9.71 |
| CHEMBL129306 | — | Kd | = | 0.2291 | nM | 9.64 |
| CHEMBL339867 | — | Kd | = | 0.537 | nM | 9.27 |
| CHEMBL126904 | — | Kd | = | 8.913 | nM | 8.05 |
| CHEMBL337942 | — | Kd | = | 10.47 | nM | 7.98 |