Assay Detail
Binding
CHEMBL694890
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Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H3 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.56 | 9.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | — | 1 | 9.88 |
| CHEMBL82298 | IMMETHRIDINE | — | 1 | 9.74 |
| CHEMBL311473 | — | — | 1 | 8.17 |
| CHEMBL90019 | IMBUTAMINE | — | 1 | 8.13 |
| CHEMBL309654 | — | — | 1 | 7.71 |
| CHEMBL78497 | — | — | 1 | 7.51 |
| CHEMBL78838 | — | — | 1 | 7.41 |
| CHEMBL82244 | — | — | 1 | 6.45 |
| CHEMBL81644 | — | — | 1 | 6.22 |
| CHEMBL79126 | — | — | 1 | 6.04 |
| CHEMBL310360 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | EC50 | = | 0.1318 | nM | 9.88 |
| CHEMBL82298 | IMMETHRIDINE | EC50 | = | 0.182 | nM | 9.74 |
| CHEMBL311473 | — | EC50 | = | 6.761 | nM | 8.17 |
| CHEMBL90019 | IMBUTAMINE | EC50 | = | 7.413 | nM | 8.13 |
| CHEMBL309654 | — | EC50 | = | 19.5 | nM | 7.71 |
| CHEMBL78497 | — | EC50 | = | 30.9 | nM | 7.51 |
| CHEMBL78838 | — | EC50 | = | 38.9 | nM | 7.41 |
| CHEMBL82244 | — | EC50 | = | 354.81 | nM | 6.45 |
| CHEMBL81644 | — | EC50 | = | 602.56 | nM | 6.22 |
| CHEMBL79126 | — | EC50 | = | 912.01 | nM | 6.04 |
| CHEMBL310360 | — | EC50 | = | 1348.96 | nM | 5.87 |