Assay Detail
Binding
CHEMBL694894
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Activity at Histamine H3 receptor expressed in CHO cells using [125I]iodoproxyfan binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.33 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14364 | — | — | 1 | 10.10 |
| CHEMBL15153 | — | — | 1 | 10.00 |
| CHEMBL15056 | — | — | 1 | 9.50 |
| CHEMBL14587 | — | — | 1 | 9.30 |
| CHEMBL276938 | — | — | 1 | 9.30 |
| CHEMBL14754 | — | — | 1 | 8.90 |
| CHEMBL14484 | — | — | 1 | 8.80 |
| CHEMBL14868 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14364 | — | Ki | = | 0.07943 | nM | 10.10 |
| CHEMBL15153 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL15056 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL14587 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL276938 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL14754 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL14484 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL14868 | — | Ki | = | 1.995 | nM | 8.70 |