Assay Detail
Binding
CHEMBL694959
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Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.71 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65250 | — | — | 1 | 6.60 |
| CHEMBL301018 | — | — | 1 | 6.54 |
| CHEMBL63676 | — | — | 1 | 6.28 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 1 | 6.10 |
| CHEMBL304929 | — | — | 1 | 6.05 |
| CHEMBL29197 | — | — | 1 | 6.00 |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | — | 1 | 5.89 |
| CHEMBL64950 | — | — | 1 | 5.80 |
| CHEMBL35820 | — | — | 1 | 5.77 |
| CHEMBL65704 | — | — | 1 | 5.68 |
| CHEMBL63244 | — | — | 1 | 5.62 |
| CHEMBL65275 | — | — | 1 | 5.54 |
| CHEMBL67008 | — | — | 1 | 5.44 |
| CHEMBL66031 | — | — | 1 | 5.40 |
| CHEMBL294769 | — | — | 1 | 5.35 |
| CHEMBL63906 | — | — | 1 | 5.26 |
| CHEMBL63786 | — | — | 1 | 5.12 |
| CHEMBL294126 | — | — | 1 | 5.04 |
| CHEMBL63469 | — | — | 1 | 4.92 |
| CHEMBL63450 | — | — | 1 | - |
| CHEMBL66409 | — | — | 1 | - |
| CHEMBL63152 | — | — | 1 | - |
| CHEMBL303996 | — | — | 1 | - |
| CHEMBL65055 | — | — | 1 | - |
| CHEMBL307526 | — | — | 1 | - |
| CHEMBL65038 | — | — | 1 | - |
| CHEMBL63917 | — | — | 1 | - |
| CHEMBL306005 | — | — | 1 | - |
| CHEMBL63203 | — | — | 1 | - |
| CHEMBL63451 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65250 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL301018 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL63676 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL752 | ADENOSINE PHOSPHATE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL304929 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL29197 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL64950 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL35820 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL65704 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL63244 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL65275 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL67008 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL66031 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL294769 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL63906 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL63786 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL294126 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL63469 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL63203 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL433251 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL67906 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL303318 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL68020 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL303292 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL63605 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL63787 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL63451 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL63450 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL306005 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL63917 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL65038 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL307526 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL65055 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL303996 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL63152 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL66409 | — | IC50 | > | 10000.0 | nM | - |