Assay Detail
Binding
CHEMBL694998
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Binding affinity against H2 receptor of Guinea pig atrium
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 4.62 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277537 | — | — | 1 | 6.00 |
| CHEMBL263070 | — | — | 1 | 5.40 |
| CHEMBL16874 | — | — | 1 | 5.30 |
| CHEMBL16274 | — | — | 1 | 5.10 |
| CHEMBL279617 | — | — | 1 | 4.90 |
| CHEMBL16108 | — | — | 1 | 4.90 |
| CHEMBL15883 | — | — | 1 | 4.90 |
| CHEMBL16654 | — | — | 1 | 4.90 |
| CHEMBL16338 | — | — | 1 | 4.80 |
| CHEMBL16592 | — | — | 1 | 4.80 |
| CHEMBL277989 | — | — | 1 | 4.80 |
| CHEMBL15813 | — | — | 1 | 4.80 |
| CHEMBL16496 | — | — | 1 | 4.50 |
| CHEMBL16565 | — | — | 1 | 4.40 |
| CHEMBL273549 | — | — | 1 | 4.40 |
| CHEMBL16109 | — | — | 1 | 4.30 |
| CHEMBL274989 | — | — | 1 | 4.20 |
| CHEMBL16056 | — | — | 1 | 4.20 |
| CHEMBL16231 | — | — | 1 | 4.10 |
| CHEMBL16639 | — | — | 1 | 4.10 |
| CHEMBL277149 | — | — | 1 | 4.10 |
| CHEMBL16957 | — | — | 1 | 4.00 |
| CHEMBL277285 | — | — | 1 | 4.00 |
| CHEMBL16373 | — | — | 1 | 4.00 |
| CHEMBL16407 | — | — | 1 | - |
| CHEMBL415989 | — | — | 1 | - |
| CHEMBL16404 | — | — | 1 | - |
| CHEMBL16142 | — | — | 1 | - |
| CHEMBL16331 | — | — | 1 | - |
| CHEMBL16401 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277537 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL263070 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL16874 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL16274 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL279617 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL16108 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL15883 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL16654 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL16338 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL16592 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL277989 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL15813 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL16496 | — | Ki | = | 31622.78 | nM | 4.50 |
| CHEMBL16565 | — | Ki | = | 39810.72 | nM | 4.40 |
| CHEMBL273549 | — | Ki | = | 39810.72 | nM | 4.40 |
| CHEMBL16109 | — | Ki | = | 50118.72 | nM | 4.30 |
| CHEMBL274989 | — | Ki | = | 63095.73 | nM | 4.20 |
| CHEMBL16056 | — | Ki | = | 63095.73 | nM | 4.20 |
| CHEMBL16231 | — | Ki | = | 79432.82 | nM | 4.10 |
| CHEMBL16639 | — | Ki | = | 79432.82 | nM | 4.10 |
| CHEMBL277149 | — | Ki | = | 79432.82 | nM | 4.10 |
| CHEMBL16957 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL277285 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL16373 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL16407 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL415989 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL16404 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL16142 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL16331 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL16401 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL274262 | — | Ki | > | 100000.0 | nM | - |