Assay Detail
Binding
CHEMBL695011
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and antiulcer activity of N-substituted N'-[3-[3-(piperidinomethyl)phenoxy]propyl]ureas: histamine H2-receptor antagonists with a potent mucosal protective activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.92 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790041 | RANITIDINE | 4.0 | 1 | 7.19 |
| CHEMBL309401 | — | — | 1 | 6.81 |
| CHEMBL81859 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790041 | RANITIDINE | Kd | = | 64.57 | nM | 7.19 |
| CHEMBL309401 | — | Kd | = | 154.88 | nM | 6.81 |
| CHEMBL81859 | — | Kd | = | 177.83 | nM | 6.75 |