Assay Detail
Functional
CHEMBL695014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Histamine H2 receptor antagonistic activity at a concentration of 1 uM on the isolated guinea pig right atrium.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.39 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70746 | — | — | 1 | 7.79 |
| CHEMBL72193 | — | — | 1 | 7.56 |
| CHEMBL307952 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70746 | — | Kd | = | 16.22 | nM | 7.79 |
| CHEMBL72193 | — | Kd | = | 27.54 | nM | 7.56 |
| CHEMBL307952 | — | Kd | = | 154.88 | nM | 6.81 |