Assay Detail
Functional
CHEMBL695249
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Inhibition of herpes simplex virus (HSV-1) in plaque reduction assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | herpes simplex virus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.24 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60469 | — | — | 1 | 5.70 |
| CHEMBL61716 | — | — | 1 | 5.54 |
| CHEMBL61003 | — | — | 1 | 5.40 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.40 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.35 |
| CHEMBL60950 | — | — | 1 | 4.80 |
| CHEMBL418640 | — | — | 1 | 4.52 |
| CHEMBL61676 | — | — | 1 | - |
| CHEMBL303055 | — | — | 1 | - |
| CHEMBL291874 | — | — | 1 | - |
| CHEMBL59959 | — | — | 1 | - |
| CHEMBL62215 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60469 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL61716 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL61003 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL184 | ACYCLOVIR | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL60950 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL418640 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL61676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL303055 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL291874 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL59959 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL62215 | — | IC50 | > | 100000.0 | nM | - |