Assay Detail
Functional
CHEMBL695250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of herpes simplex virus (HSV-1) in yield reduction assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | herpes simplex virus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.13 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.92 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.16 |
| CHEMBL60469 | — | — | 1 | 4.77 |
| CHEMBL60950 | — | — | 1 | 4.66 |
| CHEMBL61716 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL184 | ACYCLOVIR | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL60469 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL60950 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL61716 | — | IC50 | > | 100000.0 | nM | - |