Assay Detail
Functional
CHEMBL695251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antiviral activity against Herpes simplex virus (HSV-1) was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.60 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142666 | — | — | 1 | 6.48 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.51 |
| CHEMBL505732 | CHLORODEOXYURIDINE | — | 1 | 4.82 |
| CHEMBL3142658 | — | — | 1 | - |
| CHEMBL3142665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142666 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL505732 | CHLORODEOXYURIDINE | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3142658 | — | EC50 | > | 274000.0 | nM | - |
| CHEMBL3142665 | — | EC50 | > | 313000.0 | nM | - |