Assay Detail
Functional
CHEMBL695264
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Induction of transglutaminase (TGase) activity in HL-60 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.68 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 8.70 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.30 |
| CHEMBL116886 | — | — | 1 | 7.00 |
| CHEMBL118693 | — | — | 1 | 6.70 |
| CHEMBL275311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL38 | TRETINOIN | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL116886 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL118693 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL275311 | — | EC50 | > | 1000.0 | nM | - |