Assay Detail
Functional
CHEMBL695275
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In vitro cell growth inhibitory activity against HL60 cell line
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.33 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155956 | — | — | 1 | 8.96 |
| CHEMBL157559 | — | — | 1 | 8.03 |
| CHEMBL157796 | — | — | 1 | 8.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155956 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL157559 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL157796 | — | IC50 | = | 9.8 | nM | 8.01 |