Assay Detail
Functional
CHEMBL695276
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]Arachidonic acid production by stimulated HL60 (human leukemia) cells.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors--reducing the lipophilicity of the arachidonyl chain isostere.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.65 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122828 | — | — | 1 | 6.12 |
| CHEMBL330853 | — | — | 1 | 6.12 |
| CHEMBL121133 | — | — | 1 | 6.00 |
| CHEMBL120051 | — | — | 1 | 6.00 |
| CHEMBL124286 | — | — | 1 | 5.96 |
| CHEMBL121684 | — | — | 1 | 5.96 |
| CHEMBL124359 | — | — | 1 | 5.89 |
| CHEMBL122728 | — | — | 1 | 5.70 |
| CHEMBL30130 | — | — | 1 | 5.58 |
| CHEMBL333523 | — | — | 1 | 5.57 |
| CHEMBL30108 | — | — | 1 | 5.55 |
| CHEMBL121193 | — | — | 1 | 5.33 |
| CHEMBL332095 | — | — | 1 | 5.32 |
| CHEMBL121478 | — | — | 1 | 5.28 |
| CHEMBL29838 | — | — | 1 | 5.24 |
| CHEMBL119997 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122828 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL330853 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL121133 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL120051 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL124286 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL121684 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL124359 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL122728 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL30130 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL333523 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL30108 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL121193 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL332095 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL121478 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL29838 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL119997 | — | IC50 | = | 18000.0 | nM | 4.75 |