Assay Detail
Functional
CHEMBL695278
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell growth was studied in human promyelocytic leukemic (HL-60) cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cyclopent[a]anthraquinones as DNA intercalating agents with covalent bond formation potential: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.26 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.30 |
| CHEMBL94680 | — | — | 1 | 5.22 |
| CHEMBL94876 | — | — | 1 | - |
| CHEMBL97480 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL94680 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL94876 | — | IC50 | = | 123400.0 | nM | - |
| CHEMBL97480 | — | IC50 | = | 273700.0 | nM | - |