Assay Detail
Functional
CHEMBL695279
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Tested for the ability to inhibit growth in vitro against HL60
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.66 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337051 | — | — | 1 | 9.25 |
| CHEMBL134817 | — | — | 1 | 9.19 |
| CHEMBL341401 | — | — | 1 | 9.13 |
| CHEMBL132142 | — | — | 1 | 8.85 |
| CHEMBL136010 | — | — | 1 | 8.82 |
| CHEMBL132431 | — | — | 1 | 8.48 |
| CHEMBL335716 | — | — | 1 | 8.34 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.09 |
| CHEMBL134110 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337051 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL134817 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL341401 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL132142 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL136010 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL132431 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL335716 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL134110 | — | IC50 | = | 17.0 | nM | 7.77 |