Assay Detail
Functional
CHEMBL695293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to decrease the growth rate to 50% of control was evaluated against HSV-1 by using plaque reduction assay.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antiproliferative, and antiviral activity of certain 4-aminopyrrolo[2,3-d]pyridazine nucleosides: an entry into a novel series of adenosine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.19 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.47 |
| CHEMBL62099 | — | — | 1 | 5.40 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.35 |
| CHEMBL611541 | — | — | 1 | 4.52 |
| CHEMBL610706 | — | — | 1 | - |
| CHEMBL603718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL62099 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL611541 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL610706 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL603718 | — | IC50 | > | 100000.0 | nM | - |