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Assay Detail

CHEMBL695294

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Functional
Inhibitory concentration against HCMV in plaque reduction assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 1
Confidence 1 — Organism
Curated By Expert

Target

Human alphaherpesvirus 1 (CHEMBL377)
Type ORGANISM
Organism Human alphaherpesvirus 1

Publication

Synthesis and antiviral activity of certain 4- and 4,5-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines.
Pudlo JS, Saxena NK, Nassiri MR, Turk SR, Drach JC, Townsend LB.
J Med Chem (1988) 31 : 2086 -2092
PubMed 2846837 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.17 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL184 ACYCLOVIR 4.0 1 5.58
CHEMBL182 GANCICLOVIR 4.0 1 5.52
CHEMBL63480 1 4.80
CHEMBL63282 1 4.77
CHEMBL302448 1 -
CHEMBL305342 1 -
CHEMBL63714 1 -
CHEMBL63263 1 -
CHEMBL417736 1 -
CHEMBL294816 1 -
CHEMBL305300 1 -
CHEMBL293000 1 -
CHEMBL293464 1 -
CHEMBL63224 1 -
CHEMBL64017 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL184 ACYCLOVIR IC50 = 2600.0 nM 5.58
CHEMBL182 GANCICLOVIR IC50 = 3000.0 nM 5.52
CHEMBL63480 IC50 = 16000.0 nM 4.80
CHEMBL63282 IC50 = 17000.0 nM 4.77
CHEMBL302448 IC50 > 100000.0 nM -
CHEMBL305342 IC50 > 320000.0 nM -
CHEMBL63714 IC50 > 100000.0 nM -
CHEMBL63263 IC50 > 100000.0 nM -
CHEMBL417736 IC50 > 100000.0 nM -
CHEMBL294816 IC50 > 100000.0 nM -
CHEMBL305300 IC50 > 100000.0 nM -
CHEMBL293000 IC50 > 100000.0 nM -
CHEMBL293464 IC50 > 100000.0 nM -
CHEMBL63224 IC50 > 100000.0 nM -
CHEMBL64017 IC50 > 100000.0 nM -