Assay Detail
Functional
CHEMBL695382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory concentration on HIV-I nevirapine resistant strain.
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.07 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338047 | — | — | 1 | 7.40 |
| CHEMBL416107 | — | — | 1 | 6.58 |
| CHEMBL57733 | — | — | 1 | 6.00 |
| CHEMBL339511 | — | — | 2 | 6.00 |
| CHEMBL128931 | — | — | 1 | 5.89 |
| CHEMBL338936 | — | — | 1 | 5.54 |
| CHEMBL128812 | — | — | 1 | 5.35 |
| CHEMBL293498 | — | — | 1 | - |
| CHEMBL129144 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338047 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL416107 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL57733 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL339511 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL128931 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL339511 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL338936 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL128812 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL293498 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129144 | — | IC50 | > | 10000.0 | nM | - |