Assay Detail
Functional
CHEMBL695641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Histamine H3 receptor agonist activity was assessed by the inhibition of the electrically evoked twitch response of the guinea-pig ileum.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Two novel, potent and selective histamine H3 receptor agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.65 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72156 | — | — | 1 | 8.96 |
| CHEMBL19439 | IMETIT | — | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72156 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL19439 | IMETIT | IC50 | = | 4.6 | nM | 8.34 |