Assay Detail
Functional
CHEMBL695766
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Effect on specific [35S]GTP-gamma-S, Binding to HEK293 cell membranes expressing the human Histamine H3 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.85 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330688 | — | — | 1 | 7.40 |
| CHEMBL88746 | — | — | 1 | 7.01 |
| CHEMBL88958 | — | — | 1 | 6.87 |
| CHEMBL314526 | — | — | 1 | 6.51 |
| CHEMBL91361 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330688 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL88746 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL88958 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL314526 | — | EC50 | = | 311.0 | nM | 6.51 |
| CHEMBL91361 | — | EC50 | = | 366.0 | nM | 6.44 |