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Assay Detail

CHEMBL695909

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant hormone sensitive lipase.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Hormone-sensitive lipase (CHEMBL3590)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbazates as potent inhibitors of hormone-sensitive lipase.
de Jong JC, Sørensen LG, Tornqvist H, Jacobsen P.
Bioorg Med Chem Lett (2004) 14 : 1741 -1744
PubMed 15026062 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.03 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL49895 1 9.00
CHEMBL295166 1 8.52
CHEMBL49417 1 8.30
CHEMBL49896 1 8.00
CHEMBL48987 1 7.72
CHEMBL49628 1 7.62
CHEMBL49738 1 7.50
CHEMBL417000 1 7.46
CHEMBL415929 1 7.33
CHEMBL45985 1 7.30
CHEMBL51075 1 7.01
CHEMBL48254 1 6.86
CHEMBL291207 1 6.74
CHEMBL45570 1 6.69
CHEMBL45629 1 6.44
CHEMBL296709 1 6.29
CHEMBL48503 1 6.14
CHEMBL50178 1 5.50
CHEMBL416284 1 5.19
CHEMBL300955 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL49895 IC50 = 1.0 nM 9.00
CHEMBL295166 IC50 = 3.0 nM 8.52
CHEMBL49417 IC50 = 5.0 nM 8.30
CHEMBL49896 IC50 = 10.0 nM 8.00
CHEMBL48987 IC50 = 19.0 nM 7.72
CHEMBL49628 IC50 = 24.0 nM 7.62
CHEMBL49738 IC50 = 32.0 nM 7.50
CHEMBL417000 IC50 = 35.0 nM 7.46
CHEMBL415929 IC50 = 47.0 nM 7.33
CHEMBL45985 IC50 = 50.0 nM 7.30
CHEMBL51075 IC50 = 97.0 nM 7.01
CHEMBL48254 IC50 = 138.0 nM 6.86
CHEMBL291207 IC50 = 184.0 nM 6.74
CHEMBL45570 IC50 = 205.0 nM 6.69
CHEMBL45629 IC50 = 360.0 nM 6.44
CHEMBL296709 IC50 = 515.0 nM 6.29
CHEMBL48503 IC50 = 716.0 nM 6.14
CHEMBL50178 IC50 = 3200.0 nM 5.50
CHEMBL416284 IC50 = 6400.0 nM 5.19
CHEMBL300955 IC50 = 9952.0 nM 5.00