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Assay Detail

CHEMBL695916

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Functional
Tested in vitro for antiviral activity against HSV-1 in plaque reduction assay.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 1
Confidence 1 — Organism
Curated By Intermediate

Target

Human alphaherpesvirus 1 (CHEMBL377)
Type ORGANISM
Organism Human alphaherpesvirus 1

Publication

Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections.
Krawczyk SH, Bernier-Rodriguez M, Nassiri MR, Kern ER, Wotring LL, Drach JC, Townsend LB.
J Med Chem (1990) 33 : 3160 -3169
PubMed 2175356 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.05 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL184 ACYCLOVIR 4.0 1 5.40
CHEMBL182 GANCICLOVIR 4.0 1 5.35
CHEMBL101892 SANGIVAMYCIN 1 4.89
CHEMBL99668 TOYOCAMYCIN 1 4.54
CHEMBL3142826 1 -
CHEMBL3142830 1 -
CHEMBL3142823 1 -
CHEMBL3142827 1 -
CHEMBL3142824 1 -
CHEMBL3142822 1 -
CHEMBL3142821 1 -
CHEMBL3142829 1 -
CHEMBL3142825 1 -
CHEMBL3142828 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL184 ACYCLOVIR IC50 = 4000.0 nM 5.40
CHEMBL182 GANCICLOVIR IC50 = 4500.0 nM 5.35
CHEMBL101892 SANGIVAMYCIN IC50 = 13000.0 nM 4.89
CHEMBL99668 TOYOCAMYCIN IC50 = 29000.0 nM 4.54
CHEMBL3142826 IC50 > 100000.0 nM -
CHEMBL3142830 IC50 > 100000.0 nM -
CHEMBL3142823 IC50 > 100000.0 nM -
CHEMBL3142827 IC50 > 100000.0 nM -
CHEMBL3142824 IC50 > 100000.0 nM -
CHEMBL3142822 IC50 > 100000.0 nM -
CHEMBL3142821 IC50 > 100000.0 nM -
CHEMBL3142829 IC50 > 100000.0 nM -
CHEMBL3142825 IC50 > 100000.0 nM -
CHEMBL3142828 IC50 > 100000.0 nM -