Assay Detail
Functional
CHEMBL695986
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Inhibition concentration against EV-71
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterovirus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.98 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46381 | — | — | 1 | 7.40 |
| CHEMBL539766 | — | — | 1 | 7.30 |
| CHEMBL45426 | — | — | 1 | 7.22 |
| CHEMBL545191 | — | — | 1 | 7.16 |
| CHEMBL545192 | — | — | 1 | 6.85 |
| CHEMBL44346 | — | — | 1 | 6.52 |
| CHEMBL297055 | — | — | 1 | 6.48 |
| CHEMBL554790 | — | — | 1 | 6.47 |
| CHEMBL291183 | — | — | 1 | 6.46 |
| CHEMBL46646 | — | — | 1 | 6.30 |
| CHEMBL295622 | — | — | 1 | 6.25 |
| CHEMBL296696 | — | — | 1 | 6.24 |
| CHEMBL42613 | — | — | 1 | 6.24 |
| CHEMBL297352 | — | — | 1 | 6.24 |
| CHEMBL544962 | — | — | 1 | 6.23 |
| CHEMBL417175 | — | — | 1 | 6.21 |
| CHEMBL415920 | — | — | 1 | 6.18 |
| CHEMBL296288 | — | — | 1 | 5.87 |
| CHEMBL43329 | — | — | 1 | 5.87 |
| CHEMBL44596 | — | — | 1 | 5.84 |
| CHEMBL43004 | — | — | 1 | 5.82 |
| CHEMBL42292 | — | — | 1 | 5.68 |
| CHEMBL46464 | — | — | 1 | 5.68 |
| CHEMBL44969 | — | — | 1 | 5.60 |
| CHEMBL44788 | — | — | 1 | 5.58 |
| CHEMBL46704 | — | — | 1 | 5.52 |
| CHEMBL42494 | — | — | 1 | 5.33 |
| CHEMBL46424 | — | — | 1 | 5.30 |
| CHEMBL42390 | — | — | 1 | 5.26 |
| CHEMBL295554 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46381 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL539766 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL45426 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL545191 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL545192 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL44346 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL297055 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL554790 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL291183 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL46646 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL295622 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL296696 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL42613 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL297352 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL544962 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL417175 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL415920 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL296288 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL43329 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL44596 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL43004 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL42292 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL46464 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL44969 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL44788 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL46704 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL42494 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL46424 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL42390 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL295554 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL43053 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL45150 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL46920 | — | IC50 | = | 10660.0 | nM | 4.97 |
| CHEMBL296215 | — | IC50 | = | 10830.0 | nM | 4.96 |
| CHEMBL46877 | — | IC50 | = | 12040.0 | nM | 4.92 |
| CHEMBL263676 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL44929 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL297646 | — | IC50 | > | 6250.0 | nM | - |
| CHEMBL275436 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL44920 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL43311 | — | IC50 | > | 390.0 | nM | - |
| CHEMBL45194 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL295788 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL296414 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL42830 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL41999 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL46986 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL297789 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL289760 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL288103 | — | IC50 | > | 25000.0 | nM | - |