Assay Detail
Functional
CHEMBL696354
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In vitro inhibition of ADP-induced aggregation of human platelet rich plasma in the presence of pig aortal microsomes.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
[(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.12 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172280 | — | — | 1 | 5.75 |
| CHEMBL169441 | — | — | 1 | 5.75 |
| CHEMBL283656 | DAZMEGREL | 2.0 | 1 | 5.72 |
| CHEMBL172690 | — | — | 1 | 5.50 |
| CHEMBL171928 | — | — | 1 | 5.09 |
| CHEMBL173434 | — | — | 1 | 5.05 |
| CHEMBL352726 | — | — | 1 | 4.85 |
| CHEMBL173258 | — | — | 1 | 4.70 |
| CHEMBL368264 | — | — | 1 | 4.50 |
| CHEMBL174362 | — | — | 1 | 4.24 |
| CHEMBL172742 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172280 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL169441 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL283656 | DAZMEGREL | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL172690 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL171928 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL173434 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL352726 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL173258 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL368264 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL174362 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL172742 | — | IC50 | = | 180000.0 | nM | - |