Assay Detail
Functional
CHEMBL696360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HIV-2(LAV-2ROD strain) replication in MT-4 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.85 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.55 |
| CHEMBL23094 | — | — | 1 | 5.14 |
| CHEMBL31871 | HEPT | — | 1 | - |
| CHEMBL32457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL23094 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL31871 | HEPT | EC50 | > | 250000.0 | nM | - |
| CHEMBL32457 | — | EC50 | > | 100000.0 | nM | - |