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Assay Detail

CHEMBL696392

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of ADP-induced platelet aggregation in human gel-filtered platelets
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Expert

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Nonpeptide glycoprotein IIb/IIIa inhibitors: 18. Indole alpha-sulfonamide acids are potent inhibitors of platelet aggregation
Brashear KM, Cook JJ, Bednar B, Bednar RA, Gould RJ, Halczenko W, Holahan MA, Lynch RJ, Hartman GD, Hutchinson J
Bioorg Med Chem Lett (1997) 7 : 2793 -2798
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.27 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL327216 1 8.22
CHEMBL57040 1 8.10
CHEMBL96174 1 7.92
CHEMBL92091 1 7.92
CHEMBL96097 1 7.89
CHEMBL96139 1 7.82
CHEMBL94672 1 7.82
CHEMBL94393 1 7.77
CHEMBL317751 1 7.68
CHEMBL330154 1 7.35
CHEMBL96788 1 7.35
CHEMBL441810 1 7.00
CHEMBL264825 1 6.82
CHEMBL328969 1 6.55
CHEMBL94555 1 6.09
CHEMBL328727 1 6.00
CHEMBL329169 1 5.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL327216 IC50 = 6.0 nM 8.22
CHEMBL57040 IC50 = 8.0 nM 8.10
CHEMBL96174 IC50 = 12.0 nM 7.92
CHEMBL92091 IC50 = 12.0 nM 7.92
CHEMBL96097 IC50 = 13.0 nM 7.89
CHEMBL96139 IC50 = 15.0 nM 7.82
CHEMBL94672 IC50 = 15.0 nM 7.82
CHEMBL94393 IC50 = 17.0 nM 7.77
CHEMBL317751 IC50 = 21.0 nM 7.68
CHEMBL330154 IC50 = 45.0 nM 7.35
CHEMBL96788 IC50 = 45.0 nM 7.35
CHEMBL441810 IC50 = 100.0 nM 7.00
CHEMBL264825 IC50 = 150.0 nM 6.82
CHEMBL328969 IC50 = 280.0 nM 6.55
CHEMBL94555 IC50 = 810.0 nM 6.09
CHEMBL328727 IC50 = 1000.0 nM 6.00
CHEMBL329169 IC50 = 5700.0 nM 5.24