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Assay Detail

CHEMBL696460

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required to inhibit 50% growth of human Molt 4/C8 T-lymphocyte cells
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Intermediate

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Cytotoxic activities of Mannich bases of chalcones and related compounds.
Dimmock JR, Kandepu NM, Hetherington M, Quail JW, Pugazhenthi U, Sudom AM, Chamankhah M, Rose P, Pass E, Allen TM, Halleran S, Szydlowski J, Mutus B, Tannous M, Manavathu EK, Myers TG, De Clercq E, Balzarini J.
J Med Chem (1998) 41 : 1014 -1026
PubMed 9544201 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 4.90 5.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL852 MELPHALAN 4.0 1 5.49
CHEMBL555176 1 5.32
CHEMBL8014 1 5.29
CHEMBL557588 1 5.27
CHEMBL7721 1 5.25
CHEMBL545358 1 5.24
CHEMBL557383 1 5.24
CHEMBL266780 1 5.23
CHEMBL7457 1 5.22
CHEMBL8015 1 5.20
CHEMBL7709 1 5.17
CHEMBL7531 1 5.16
CHEMBL555363 1 5.16
CHEMBL542780 1 5.15
CHEMBL7803 1 5.10
CHEMBL552815 1 5.10
CHEMBL545127 1 5.08
CHEMBL545593 1 5.08
CHEMBL538847 1 5.08
CHEMBL7747 4-HYDROXYCHALCONE 1 5.07
CHEMBL7668 1 5.03
CHEMBL274170 1 4.97
CHEMBL545128 1 4.91
CHEMBL7976 CHALCONE 1 4.90
CHEMBL276473 4'-HYDROXYCHALCONE 1 4.88
CHEMBL274303 1 4.86
CHEMBL536104 1 4.81
CHEMBL8102 1 4.79
CHEMBL544894 1 4.76
CHEMBL542045 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL852 MELPHALAN IC50 = 3240.0 nM 5.49
CHEMBL555176 IC50 = 4820.0 nM 5.32
CHEMBL8014 IC50 = 5150.0 nM 5.29
CHEMBL557588 IC50 = 5380.0 nM 5.27
CHEMBL7721 IC50 = 5660.0 nM 5.25
CHEMBL545358 IC50 = 5740.0 nM 5.24
CHEMBL557383 IC50 = 5750.0 nM 5.24
CHEMBL266780 IC50 = 5940.0 nM 5.23
CHEMBL7457 IC50 = 6070.0 nM 5.22
CHEMBL8015 IC50 = 6330.0 nM 5.20
CHEMBL7709 IC50 = 6800.0 nM 5.17
CHEMBL555363 IC50 = 6990.0 nM 5.16
CHEMBL7531 IC50 = 6910.0 nM 5.16
CHEMBL542780 IC50 = 7130.0 nM 5.15
CHEMBL552815 IC50 = 7920.0 nM 5.10
CHEMBL7803 IC50 = 7880.0 nM 5.10
CHEMBL545127 IC50 = 8420.0 nM 5.08
CHEMBL545593 IC50 = 8410.0 nM 5.08
CHEMBL538847 IC50 = 8300.0 nM 5.08
CHEMBL7747 4-HYDROXYCHALCONE IC50 = 8580.0 nM 5.07
CHEMBL7668 IC50 = 9380.0 nM 5.03
CHEMBL274170 IC50 = 10800.0 nM 4.97
CHEMBL545128 IC50 = 12400.0 nM 4.91
CHEMBL7976 CHALCONE IC50 = 12700.0 nM 4.90
CHEMBL276473 4'-HYDROXYCHALCONE IC50 = 13100.0 nM 4.88
CHEMBL274303 IC50 = 13900.0 nM 4.86
CHEMBL536104 IC50 = 15400.0 nM 4.81
CHEMBL8102 IC50 = 16100.0 nM 4.79
CHEMBL544894 IC50 = 17200.0 nM 4.76
CHEMBL542045 IC50 = 17200.0 nM 4.76
CHEMBL269163 IC50 = 18200.0 nM 4.74
CHEMBL537255 IC50 = 20700.0 nM 4.68
CHEMBL537011 IC50 = 25300.0 nM 4.60
CHEMBL7973 IC50 = 25400.0 nM 4.59
CHEMBL266293 IC50 = 27900.0 nM 4.55
CHEMBL268559 IC50 = 27900.0 nM 4.55
CHEMBL440640 IC50 = 30300.0 nM 4.52
CHEMBL7575 IC50 = 30800.0 nM 4.51
CHEMBL536784 IC50 = 39200.0 nM 4.41
CHEMBL8067 IC50 = 39200.0 nM 4.41
CHEMBL545130 IC50 = 40200.0 nM 4.40
CHEMBL545595 IC50 = 44300.0 nM 4.35
CHEMBL558976 IC50 = 98000.0 nM 4.01
CHEMBL7809 IC50 = 220000.0 nM -