Assay Detail
Functional
CHEMBL696490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound is evaluated for histamine H2 receptor agonistic activity in guinea pig cerebral cortex using [3H]tiotidine as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 4.72 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554964 | — | — | 1 | 5.30 |
| CHEMBL111215 | — | — | 1 | 4.82 |
| CHEMBL12344 | DIMAPRIT | — | 1 | 4.58 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 4.16 |
| CHEMBL324864 | — | — | 1 | - |
| CHEMBL540311 | — | — | 1 | - |
| CHEMBL553981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554964 | — | Kd | = | 5011.87 | nM | 5.30 |
| CHEMBL111215 | — | Kd | = | 15135.61 | nM | 4.82 |
| CHEMBL12344 | DIMAPRIT | Kd | = | 26302.68 | nM | 4.58 |
| CHEMBL90 | HISTAMINE | Kd | = | 69183.1 | nM | 4.16 |
| CHEMBL324864 | — | Kd | = | 109647.82 | nM | - |
| CHEMBL540311 | — | Kd | = | 354813.39 | nM | - |
| CHEMBL553981 | — | Kd | = | 173780.08 | nM | - |