Assay Detail
Binding
CHEMBL696492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]APT binding to H2 receptors in guinea pig cerebral membranes.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.93 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73994 | — | — | 1 | 8.58 |
| CHEMBL304608 | — | — | 1 | 8.28 |
| CHEMBL269646 | TIOTIDINE | 2.0 | 1 | 8.25 |
| CHEMBL72844 | AMINOPOTENTIDINE | — | 1 | 8.01 |
| CHEMBL30 | CIMETIDINE | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73994 | — | Ki | = | 2.63 | nM | 8.58 |
| CHEMBL304608 | — | Ki | = | 5.248 | nM | 8.28 |
| CHEMBL269646 | TIOTIDINE | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL72844 | AMINOPOTENTIDINE | Ki | = | 9.772 | nM | 8.01 |
| CHEMBL30 | CIMETIDINE | Ki | = | 302.0 | nM | 6.52 |