Assay Detail
Binding
CHEMBL696493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]APT binding to histamine H2 receptor in guinea pig cerebral membranes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.11 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72193 | — | — | 1 | 9.15 |
| CHEMBL307952 | — | — | 1 | 7.92 |
| CHEMBL1790041 | RANITIDINE | 4.0 | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72193 | — | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL307952 | — | Ki | = | 12.02 | nM | 7.92 |
| CHEMBL1790041 | RANITIDINE | Ki | = | 53.7 | nM | 7.27 |