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Assay Detail

CHEMBL696526

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant IL-1 beta converting enzyme
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Caspase-1 (CHEMBL4801)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Peptidomimetic aminomethylene ketone inhibitors of interleukin-1 beta-converting enzyme (ICE).
Semple G, Ashworth DM, Batt AR, Baxter AJ, Benzies DW, Elliot LH, Evans DM, Franklin RJ, Hudson P, Jenkins PD, Pitt GR, Rooker DP, Yamamoto S, Isomura Y.
Bioorg Med Chem Lett (1998) 8 : 959 -964
PubMed 9871520 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 30 7.80 9.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL115090 1 9.43
CHEMBL366456 1 9.12
CHEMBL366534 1 9.07
CHEMBL368313 1 8.94
CHEMBL176584 1 8.75
CHEMBL176512 1 8.64
CHEMBL368078 1 8.62
CHEMBL369634 1 8.52
CHEMBL173677 1 8.51
CHEMBL177364 1 8.40
CHEMBL367714 1 8.32
CHEMBL424953 1 8.14
CHEMBL172900 1 8.10
CHEMBL172196 1 7.95
CHEMBL369589 1 7.94
CHEMBL435520 1 7.64
CHEMBL367715 1 7.60
CHEMBL366506 1 7.46
CHEMBL174581 1 7.43
CHEMBL172905 1 7.35
CHEMBL172040 1 7.24
CHEMBL355585 1 7.24
CHEMBL171846 1 7.20
CHEMBL173116 1 7.11
CHEMBL172921 1 7.09
CHEMBL174395 1 6.93
CHEMBL367294 1 6.59
CHEMBL172549 1 6.40
CHEMBL173528 1 6.39
CHEMBL425849 1 5.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL115090 Ki = 0.37 nM 9.43
CHEMBL366456 Ki = 0.76 nM 9.12
CHEMBL366534 Ki = 0.85 nM 9.07
CHEMBL368313 Ki = 1.15 nM 8.94
CHEMBL176584 Ki = 1.79 nM 8.75
CHEMBL176512 Ki = 2.3 nM 8.64
CHEMBL368078 Ki = 2.39 nM 8.62
CHEMBL369634 Ki = 3.05 nM 8.52
CHEMBL173677 Ki = 3.1 nM 8.51
CHEMBL177364 Ki = 4.0 nM 8.40
CHEMBL367714 Ki = 4.8 nM 8.32
CHEMBL424953 Ki = 7.3 nM 8.14
CHEMBL172900 Ki = 8.0 nM 8.10
CHEMBL172196 Ki = 11.25 nM 7.95
CHEMBL369589 Ki = 11.6 nM 7.94
CHEMBL435520 Ki = 22.8 nM 7.64
CHEMBL367715 Ki = 25.0 nM 7.60
CHEMBL366506 Ki = 34.3 nM 7.46
CHEMBL174581 Ki = 37.0 nM 7.43
CHEMBL172905 Ki = 45.0 nM 7.35
CHEMBL172040 Ki = 58.0 nM 7.24
CHEMBL355585 Ki = 57.5 nM 7.24
CHEMBL171846 Ki = 62.5 nM 7.20
CHEMBL173116 Ki = 78.0 nM 7.11
CHEMBL172921 Ki = 81.0 nM 7.09
CHEMBL174395 Ki = 117.0 nM 6.93
CHEMBL367294 Ki = 255.0 nM 6.59
CHEMBL172549 Ki = 395.0 nM 6.40
CHEMBL173528 Ki = 410.0 nM 6.39
CHEMBL425849 Ki = 1650.0 nM 5.78