Assay Detail
Functional
CHEMBL696546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potency
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.76 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.42 |
| CHEMBL330638 | — | — | 1 | 8.04 |
| CHEMBL99123 | — | — | 1 | 7.96 |
| CHEMBL100219 | — | — | 1 | 7.92 |
| CHEMBL419158 | — | — | 1 | 7.80 |
| CHEMBL97206 | — | — | 1 | 7.80 |
| CHEMBL317578 | — | — | 1 | 7.58 |
| CHEMBL95644 | — | — | 1 | 7.50 |
| CHEMBL327757 | — | — | 1 | 7.31 |
| CHEMBL99046 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL330638 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL99123 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL100219 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL419158 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL97206 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL317578 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL95644 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL327757 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL99046 | — | IC50 | = | 51.0 | nM | 7.29 |