Assay Detail
Functional
CHEMBL696573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for its inhibition of the classical pathway activation of human complement
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.38 | 4.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55273 | — | — | 1 | 4.50 |
| CHEMBL56287 | — | — | 1 | 4.50 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.14 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
| CHEMBL366695 | — | — | 1 | - |
| CHEMBL293311 | — | — | 1 | - |
| CHEMBL298623 | — | — | 1 | - |
| CHEMBL457064 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55273 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL56287 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 72300.0 | nM | 4.14 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 577000.0 | nM | - |
| CHEMBL366695 | — | IC50 | = | 233700.0 | nM | - |
| CHEMBL293311 | — | IC50 | = | 108300.0 | nM | - |
| CHEMBL298623 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL457064 | — | IC50 | = | 146000.0 | nM | - |