Assay Detail
Functional
CHEMBL696582
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Inhibitory activity against aggregation of human platelet-rich plasma(induced by 4 uM of U-46619)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro activity of stereoisomers of a novel thromboxane receptor antagonist, (+-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo [2.2.1]hept-2-exo-yl]heptenoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.97 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2448578 | — | — | 1 | 7.22 |
| CHEMBL1744350 | — | — | 1 | 6.35 |
| CHEMBL266243 | ONO-3708 | — | 1 | 6.05 |
| CHEMBL266225 | — | — | 1 | 5.60 |
| CHEMBL8101 | — | — | 1 | 5.48 |
| CHEMBL8273 | SULOTROBAN | 2.0 | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2448578 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1744350 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL266243 | ONO-3708 | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL266225 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL8101 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL8273 | SULOTROBAN | IC50 | = | 7200.0 | nM | 5.14 |