Assay Detail
Functional
CHEMBL696684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of 5.86 uM ADP-induced human platelet aggregation in platelet rich plasma (PRP)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5- oxazolyl]phenoxy]acetic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.89 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 8.70 |
| CHEMBL125569 | — | — | 1 | 7.57 |
| CHEMBL127432 | — | — | 1 | 7.30 |
| CHEMBL127616 | — | — | 1 | 6.75 |
| CHEMBL326075 | — | — | 1 | 6.75 |
| CHEMBL340197 | — | — | 1 | 6.19 |
| CHEMBL338107 | — | — | 1 | 5.97 |
| CHEMBL117835 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL125569 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL127432 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL127616 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL326075 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL340197 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL338107 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL117835 | — | IC50 | = | 1200.0 | nM | 5.92 |