Assay Detail
Functional
CHEMBL696685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of ADP-induced platelet aggregation using human platelet rich plasma
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.91 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 8.60 |
| CHEMBL132589 | — | — | 1 | 7.22 |
| CHEMBL335051 | — | — | 1 | 6.96 |
| CHEMBL132649 | — | — | 1 | 6.28 |
| CHEMBL117835 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL132589 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL335051 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL132649 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL117835 | — | IC50 | = | 3400.0 | nM | 5.47 |