Assay Detail
Functional
CHEMBL696696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-terminus urea-substituted chemotactic peptides: new potent agonists and antagonists toward the neutrophil fMLF receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.49 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267388 | — | — | 1 | 9.00 |
| CHEMBL7753 | — | — | 1 | 9.00 |
| CHEMBL266802 | — | — | 1 | 8.70 |
| CHEMBL267179 | N-FORMYLMETHIONYL-LEUCYLPHENYLALANINE | — | 1 | 7.70 |
| CHEMBL7520 | — | — | 1 | 7.40 |
| CHEMBL265408 | — | — | 1 | 6.52 |
| CHEMBL6997 | — | — | 1 | 6.05 |
| CHEMBL7306 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267388 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL7753 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL266802 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL267179 | N-FORMYLMETHIONYL-LEUCYLPHENYLALANINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL7520 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL265408 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL6997 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL7306 | — | EC50 | = | 3000.0 | nM | 5.52 |