Assay Detail
Functional
CHEMBL696699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of LTB4 receptor induced CD11b/CD18 adhesion protein up-regulation in human neutrophil
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Acid unit modifications of 1,2,4,5-substituted hydroxyacetophenones and the effect on in vitro and in vivo LTB4 receptor antagonism
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.61 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15559 | — | — | 1 | 5.80 |
| CHEMBL15817 | — | — | 1 | 5.73 |
| CHEMBL15295 | — | — | 1 | 5.71 |
| CHEMBL15766 | LY-255283 | — | 1 | 5.54 |
| CHEMBL15299 | — | — | 1 | 5.49 |
| CHEMBL15648 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15559 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL15817 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL15295 | — | IC50 | = | 1941.0 | nM | 5.71 |
| CHEMBL15766 | LY-255283 | IC50 | = | 2874.0 | nM | 5.54 |
| CHEMBL15299 | — | IC50 | = | 3271.0 | nM | 5.49 |
| CHEMBL15648 | — | IC50 | = | 4388.0 | nM | 5.36 |