Assay Detail
Functional
CHEMBL696907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit 50% growth of Human CEM T-lymphocytes cells
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cytotoxic activities of Mannich bases of chalcones and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.14 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8014 | — | — | 1 | 5.87 |
| CHEMBL538847 | — | — | 1 | 5.81 |
| CHEMBL7721 | — | — | 1 | 5.77 |
| CHEMBL555176 | — | — | 1 | 5.76 |
| CHEMBL8015 | — | — | 1 | 5.73 |
| CHEMBL7457 | — | — | 1 | 5.70 |
| CHEMBL266780 | — | — | 1 | 5.65 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.61 |
| CHEMBL555363 | — | — | 1 | 5.61 |
| CHEMBL557383 | — | — | 1 | 5.57 |
| CHEMBL536104 | — | — | 1 | 5.54 |
| CHEMBL8102 | — | — | 1 | 5.48 |
| CHEMBL7531 | — | — | 1 | 5.46 |
| CHEMBL7803 | — | — | 1 | 5.45 |
| CHEMBL557588 | — | — | 1 | 5.36 |
| CHEMBL545127 | — | — | 1 | 5.32 |
| CHEMBL545358 | — | — | 1 | 5.31 |
| CHEMBL7709 | — | — | 1 | 5.27 |
| CHEMBL268559 | — | — | 1 | 5.23 |
| CHEMBL542045 | — | — | 1 | 5.21 |
| CHEMBL545593 | — | — | 1 | 5.19 |
| CHEMBL552815 | — | — | 1 | 5.11 |
| CHEMBL542780 | — | — | 1 | 5.09 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | — | 1 | 5.03 |
| CHEMBL7575 | — | — | 1 | 5.00 |
| CHEMBL274303 | — | — | 1 | 4.99 |
| CHEMBL545128 | — | — | 1 | 4.98 |
| CHEMBL266293 | — | — | 1 | 4.97 |
| CHEMBL7973 | — | — | 1 | 4.95 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8014 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL538847 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL7721 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL555176 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL8015 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL7457 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL266780 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL852 | MELPHALAN | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL555363 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL557383 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL536104 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL8102 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL7531 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL7803 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL557588 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL545127 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL545358 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL7709 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL268559 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL542045 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL545593 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL552815 | — | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL542780 | — | IC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL7575 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL274303 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL545128 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL266293 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL7973 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL7976 | CHALCONE | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL7668 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL8067 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL269163 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL544894 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL537011 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL537255 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL274170 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL536784 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL558976 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL545130 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL545595 | — | IC50 | = | 39100.0 | nM | 4.41 |
| CHEMBL7809 | — | IC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL440640 | — | IC50 | = | 78600.0 | nM | 4.11 |