Assay Detail
Functional
CHEMBL696950
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Antiviral activity against Human Cytomegalovirus (HCMV) replication in a plaque reduction assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and ++thiosangivamycin: influence of various 7-substituents on antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.75 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101892 | SANGIVAMYCIN | — | 1 | 7.52 |
| CHEMBL99668 | TOYOCAMYCIN | — | 1 | 7.30 |
| CHEMBL172389 | — | — | 1 | 7.00 |
| CHEMBL444609 | — | — | 1 | 7.00 |
| CHEMBL171699 | — | — | 1 | 6.70 |
| CHEMBL171791 | — | — | 1 | 6.60 |
| CHEMBL172213 | — | — | 1 | 6.44 |
| CHEMBL170107 | — | — | 1 | 6.30 |
| CHEMBL117969 | — | — | 1 | 6.00 |
| CHEMBL51847 | — | — | 1 | 5.92 |
| CHEMBL299814 | — | — | 1 | 5.92 |
| CHEMBL172175 | — | — | 1 | 5.82 |
| CHEMBL171741 | — | — | 1 | 5.80 |
| CHEMBL48547 | — | — | 1 | 5.68 |
| CHEMBL368561 | — | — | 1 | 5.58 |
| CHEMBL116194 | — | — | 1 | 5.57 |
| CHEMBL171253 | — | — | 1 | 5.47 |
| CHEMBL168415 | TOYOCAMYCIN AGLYCONE | — | 1 | 5.41 |
| CHEMBL300485 | — | — | 1 | 5.21 |
| CHEMBL30286 | — | — | 1 | 5.06 |
| CHEMBL171941 | — | — | 1 | 4.89 |
| CHEMBL422566 | — | — | 1 | 4.82 |
| CHEMBL169748 | — | — | 1 | 4.55 |
| CHEMBL171633 | — | — | 1 | 4.50 |
| CHEMBL50996 | — | — | 1 | 4.44 |
| CHEMBL115708 | — | — | 1 | 4.05 |
| CHEMBL169045 | — | — | 1 | - |
| CHEMBL297745 | — | — | 1 | - |
| CHEMBL300084 | — | — | 1 | - |
| CHEMBL353190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101892 | SANGIVAMYCIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL99668 | TOYOCAMYCIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL444609 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL172389 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL171699 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL171791 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL172213 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL170107 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL117969 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL51847 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL299814 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL172175 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL171741 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL48547 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL368561 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL116194 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL171253 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL168415 | TOYOCAMYCIN AGLYCONE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL300485 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL30286 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL171941 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL422566 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL169748 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL171633 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL50996 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL115708 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL48444 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL353648 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL171101 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL165883 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL355693 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL435968 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL169096 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL297893 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL171678 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL169207 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL171109 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL355332 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL353190 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL300084 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL297745 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL169045 | — | IC50 | > | 100000.0 | nM | - |