Compound Detail
CHEMBL168415
TOYOCAMYCIN AGLYCONE Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL168415 |
| Name | TOYOCAMYCIN AGLYCONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GFIPINBJCGELKW-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
159.2
MW (Da)
0.41
ALogP
4
HBA
2
HBD
91.4
PSA (Ų)
0.58
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human betaherpesvirus 5 CHEMBL371 | IC50 | 5.41 | 5.41 | 3900.0 | 1 |
| HFF CHEMBL614071 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
| KB CHEMBL398 | IC50 | 4.75 | 4.75 | 18000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human betaherpesvirus 5 | IC50 | = | 3900.0 | nM | 5.41 | Antiviral activity against Human Cytomegalovirus (HCMV) replication in a plaque ... | 8632411 |
| HFF | IC50 | = | 10000.0 | nM | 5.0 | Cytotoxicity against HFF cells, estimated by visual scoring of cells not affecte... | 8632411 |
| KB | IC50 | = | 18000.0 | nM | 4.75 | Cytotoxic activity tested against exponentially growing KB cells, determined by ... | 8632411 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8632411 | 10.1021/jm950444j | Human betaherpesvirus 5 | 1 |
| 8632411 | 10.1021/jm950444j | Human alphaherpesvirus 1 | 1 |
| 8632411 | 10.1021/jm950444j | HFF | 1 |
| 8632411 | 10.1021/jm950444j | KB | 1 |
| 2693614 | 10.1021/np50066a032 | Candida albicans | 1 |
| 2693614 | 10.1021/np50066a032 | L1210 | 1 |
| 26883470 | 10.1021/acs.jnatprod.5b00987 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine